The AI Challenges
We’re Building For
AI in medicine presents enormous opportunities — and also serious risks. Healthcare deserves AI systems that address these challenges directly.
These principles guide our research, product development, governance, and partnerships as we build the safety layer for clinical AI.
Drs. Joe Habboushe, Graham Walker & Shazia Siddique
Challenge #1 — Patient Privacy
Healthcare runs on trust. No patient expects their medical information to be shared with an AI system without their consent. Yet many clinicians underestimate how easily protected health information can be exposed through modern workflows — and how irreversible those accidental disclosures can be.
We believe protecting patient privacy is foundational to medical AI systems that are worthy of patients’ and clinicians’ trust.
How we’re addressing this
CrossCover is designed to detect potentially identifying health information before it is sent to an AI model and give clinicians the opportunity to redact it. PHI protections operate at multiple points in the workflow, adding redundant safeguards around sensitive patient information.
Challenge #2 — Hallucinations
Generative AI systems can be confidently wrong.
Sometimes the error is obvious — a paper that doesn’t exist. As models have improved, hallucination rates have decreased, but have not disappeared. If anything, they’re just harder to spot: small differences in medication doses compared to current guidelines, or a confidently incorrect recommendation.
In medicine, we know that even small inaccuracies and nuances have significant consequences.
How we’re addressing this
Our novel CrossCheck™ feature, currently in beta, independently checks clinical AI output against authoritative medical references, surfacing areas of agreement, disagreement, and uncertainty for clinicians to review. We also encourage our AI partners to provide source transparency, and we plan to publish trends we observe over time — because clinicians should be able to see where AI performs well and where it still falls short.
Challenge #3 — General Bias
Research demonstrates that generative AI systems can produce different recommendations based on patient demographics, language, geography, or socioeconomic status. Some bias in medicine makes clinical sense: excluding an elderly patient from a diagnosis of Kawasaki’s disease; providing closer followup for a concert pianist with a flexor tendon injury. Other biases can reinforce existing inequities in healthcare and create risk for both patients and clinicians.
We believe bias should be measured, monitored, and made transparent.
How we’re addressing this
CrossCover is being designed to test for and surface patterns of bias in clinical AI output, while working with model partners to understand and address issues when they appear.
Challenge #4 — Liability
Who is responsible when AI gets it wrong?
As AI becomes more deeply integrated into clinical workflows, questions surrounding accountability and liability become increasingly important.
We believe healthcare organizations need governance structures that preserve physician oversight, accountability, and clear lines of responsibility.
How we’re addressing this
CrossCover is designed to keep physicians in control of the final clinical decision while creating greater visibility into the evidence, assumptions, and uncertainty behind AI-generated information. We’re also working with clinicians, health systems, legal experts, and other stakeholders to help define responsible governance for clinical AI.
Challenge #6 — Clinical Deskilling
AI should augment expertise — not replace it.
Research increasingly suggests that excessive reliance on AI can reduce independent clinical performance over time. Meanwhile, cognitive science and psychology literature suggest that generative AI tools are frequently used in areas of low confidence.
If clinicians do not maintain our clinical competence, they can enter a downward spiral of lower confidence as well. And healthcare must carefully balance efficiency with maintaining clinical expertise.
How we’re addressing this
CrossCheck, currently in beta, is designed to keep clinicians engaged by surfacing the evidence, assumptions, and areas of uncertainty behind AI-generated clinical information. The goal isn’t to make the decision for the physician — it’s to help physicians identify possible areas to look at more closely.
Challenge #7 — Evidence
Medicine depends on evidence that can be trusted.
As AI-generated content floods the internet, future models may increasingly train on synthetic information rather than primary evidence, and even the motivations for new scientific discoveries may change.
The results may be a growing risk of self-reinforcing inaccuracies that become harder to detect over time, and fewer novel discoveries and ideas.
How we’re addressing this
CrossCover grounds its analysis in peer-reviewed medical sources, making it easier for clinicians to see the evidence behind an AI-generated answer and evaluate it for themselves. As AI-generated content proliferates, preserving a clear connection to primary evidence becomes even more important.